InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spink3

Summary

InnateDB Protein

IDBP-144008.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spink3

Protein Name

serine peptidase inhibitor, Kazal type 3

Synonyms

p12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025381

InnateDB Gene

IDBG-144006 (Spink3)

Protein Structure

UniProt Annotation

Function

Serine protease inhibitor which exhibits anti-trypsin activity. Inhibits the uptake of calcium by spermatozoa. {ECO:0000269PubMed:3428272, ECO:0000269PubMed:9828198}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

In the genital tract, expressed only in male accessory glands including seminal vesicle, coagulating gland and prostate. {ECO:0000269PubMed:9828198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0010466	negative regulation of peptidase activity
GO:0010751	negative regulation of nitric oxide mediated signal transduction
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0060046	regulation of acrosome reaction
GO:0090281	negative regulation of calcium ion import
GO:1900004	negative regulation of serine-type endopeptidase activity
GO:2001256	regulation of store-operated calcium entry

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:106202

InterPro

IPR001239 Proteinase inhibitor I1, Kazal metazoa
IPR002350 Kazal domain

PFAM

PF00050
PF07648

PRINTS

PR00290

PIRSF

SMART

SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P09036

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

20730

UniGene

RefSeq

NP_033284

MGI ID

MGI Symbol

Spink3

OMIM

CCDS

CCDS37803

HPRD

IMGT

EMBL

AK007841 AK007985 BC086887 X06342

GenPept

AAH86887 BAB25298 BAB25389 CAA29648