InnateDB Protein
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IDBP-144023.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Insig1
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Protein Name
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insulin induced gene 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000061877
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InnateDB Gene
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IDBG-144021 (Insig1)
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Protein Structure
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Function |
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916289
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InterPro |
IPR025929
Insulin-induced protein family
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PFAM |
PF07281
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BGI3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
231070
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UniGene |
Mm.470370
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RefSeq |
NP_705746
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MGI ID |
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MGI Symbol |
Insig1
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OMIM |
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CCDS |
CCDS19142
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HPRD |
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IMGT |
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EMBL |
AF527630
AK088380
AK135941
AK139913
AK151186
BC132167
BC132499
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GenPept |
AAI32168
AAI32500
AAN28331
BAC40316
BAE22733
BAE24179
BAE30185
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