Version 5.4
Mus musculus Protein: E430025E21Rik
Summary
InnateDB Protein IDBP-144055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E430025E21Rik
Protein Name RIKEN cDNA E430025E21 gene
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000022976
InnateDB Gene IDBG-144053 (E430025E21Rik)
Protein Structure
UniProt Annotation
Function Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0016197 endosomal transport
Cellular Component
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0071203 WASH complex
Protein Structure and Domains
PDB ID MGI:2146110
InterPro IPR014756 Immunoglobulin E-set
IPR019393 WASH complex, subunit strumpellin
PFAM PF10266
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C2E7
PhosphoSite PhosphoSite-Q8C2E7
TrEMBL Q3TQ26
UniProt Splice Variant
Entrez Gene 223593
UniGene
RefSeq NP_705776
MGI ID
MGI Symbol E430025E21Rik
OMIM
CCDS CCDS37083
HPRD
IMGT
EMBL AK088754 AK129086 AK163968 BC031364 BC034070 BC040815 BC067035
GenPept AAH31364 AAH34070 AAH40815 AAH67035 BAC40548 BAC97896 BAE37559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca