Version 5.4
Mus musculus Protein: Sdhaf2
Summary
InnateDB Protein IDBP-144131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sdhaf2
Protein Name succinate dehydrogenase complex assembly factor 2
Synonyms 0610038F07Rik; AA407634; AW049997;
Species Mus musculus
Ensembl Protein ENSMUSP00000025570
InnateDB Gene IDBG-144129 (Sdhaf2)
Protein Structure
UniProt Annotation
Function Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment. {ECO:0000255HAMAP- Rule:MF_03057}.
Subcellular Localization Mitochondrion {ECO:0000255HAMAP- Rule:MF_03057}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006121 mitochondrial electron transport, succinate to ubiquinone
GO:0018293 protein-FAD linkage
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1913322
InterPro IPR005631 Flavinator of succinate dehydrogenase
PFAM PF03937
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C6I2
PhosphoSite PhosphoSite-Q8C6I2
TrEMBL
UniProt Splice Variant
Entrez Gene 66072
UniGene Mm.411039
RefSeq NP_079609
MGI ID
MGI Symbol Sdhaf2
OMIM
CCDS CCDS29578
HPRD
IMGT
EMBL AK013454 AK075594 AK160175 AK160957 AK167228 BC029630 BC038924 BC048913 BC060090 BC085277
GenPept AAH29630 AAH38924 AAH48913 AAH60090 AAH85277 BAB28863 BAC35843 BAE35674 BAE36113 BAE39352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca