Version 5.4
Mus musculus Protein: Cobra1
Summary
InnateDB Protein IDBP-144138.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cobra1
Protein Name cofactor of BRCA1
Synonyms A730008L03Rik; AB041607; AI663983; Cobra1; Nelf-b;
Species Mus musculus
Ensembl Protein ENSMUSP00000057731
InnateDB Gene IDBG-144134 (Cobra1)
Protein Structure
UniProt Annotation
Function Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032021 NELF complex
Protein Structure and Domains
PDB ID MGI:1931035
InterPro IPR010405 Cofactor of BRCA1
PFAM PF06209
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C4Y3
PhosphoSite PhosphoSite-Q8C4Y3
TrEMBL Q69ZP4
UniProt Splice Variant
Entrez Gene 58202
UniGene Mm.116418
RefSeq NP_067368
MGI ID
MGI Symbol Nelfb
OMIM
CCDS CCDS15751
HPRD
IMGT
EMBL AB041607 AK080419 AK173124 BC004762
GenPept AAH04762 BAA95090 BAD32402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca