InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp746

Summary

InnateDB Protein

IDBP-144200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp746

Protein Name

zinc finger protein 746

Synonyms

2810407L07Rik; AI317225; Znf746;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072868

InnateDB Gene

IDBG-144198 (Zfp746)

Protein Structure

UniProt Annotation

Function

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. In brain, it is heterogeneously distributed throughout the brain and localizes to neurons, including substantia nigra pars compacta dopamine- containing neurons. Weakly expressed in cerebellum and midbrain (at protein level). {ECO:0000269PubMed:21376232}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010941	regulation of cell death
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070997	neuron death

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1916478

InterPro

IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR022137 Protein of unknown function DUF3669, zinc finger protein

PFAM

PF01352
PF00096
PF12417

PRINTS

PIRSF

SMART

SM00349
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3U133