InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAZAP1

Summary

InnateDB Protein

IDBP-14429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAZAP1

Protein Name

DAZ associated protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000233078

InnateDB Gene

IDBG-14425 (DAZAP1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein, which may be required during spermatogenesis.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22001406}. Nucleus {ECO:0000269PubMed:22001406}. Note=Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:10857750}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0035613	RNA stem-loop binding
GO:0044822	poly(A) RNA binding