Version 5.4
Mus musculus Protein: Spinkl
Summary
InnateDB Protein IDBP-144337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spinkl
Protein Name serine protease inhibitor, Kazal type-like
Synonyms 9530002K18Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000063376
InnateDB Gene IDBG-144335 (Spinkl)
Protein Structure
UniProt Annotation
Function Does not function as an inhibitor of trypsin, chymotrypsin, subtilisin or elastase. Binds sperm and enhances sperm motility. May act as a decapacitation factor, suppresses BSA-stimulated sperm capacitation and blocks sperm-oocyte interactions in vitro. {ECO:0000269PubMed:18715980}.
Subcellular Localization Secreted {ECO:0000269PubMed:18715980}.
Disease Associations
Tissue Specificity Luminal fluid and mucosal folds of the seminal vesicles (at protein level). Not detected in brain, heart, lung, liver, kidney, stomach, small intestine, muscle, skin, thymus, placenta or bladder. {ECO:0000269PubMed:18715980}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:1902093 positive regulation of sperm motility
GO:1902491 negative regulation of sperm capacitation
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1924674
InterPro IPR002350 Kazal domain
PFAM PF00050
PF07648
PRINTS
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CEK3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 77424
UniGene Mm.99224
RefSeq NP_898946
MGI ID
MGI Symbol Spinkl
OMIM
CCDS CCDS50273
HPRD
IMGT
EMBL AK020535
GenPept BAC25634

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca