Version 5.4
Mus musculus Protein: Lsm1
Summary
InnateDB Protein IDBP-144460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lsm1
Protein Name LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms 2810025O06Rik; CASM;
Species Mus musculus
Ensembl Protein ENSMUSP00000041022
InnateDB Gene IDBG-144458 (Lsm1)
Protein Structure
UniProt Annotation
Function Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0071044 histone mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:1914457
InterPro IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
PFAM PF01423
PRINTS
PIRSF
SMART SM00651
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VC85
PhosphoSite PhosphoSite-Q8VC85
TrEMBL Q9CRP6
UniProt Splice Variant
Entrez Gene 67207
UniGene
RefSeq NP_080308
MGI ID
MGI Symbol Lsm1
OMIM
CCDS CCDS22202
HPRD
IMGT
EMBL AK006006 AK012814 AK019398 AK041290 BC021460 CH466580
GenPept AAH21460 BAB24361 BAB28489 BAB31701 BAC30891 EDL32821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca