InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Star

Summary

InnateDB Protein

IDBP-144485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Star

Protein Name

steroidogenic acute regulatory protein

Synonyms

AV363654; D8Ertd419e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033979

InnateDB Gene

IDBG-144483 (Star)

Protein Structure

UniProt Annotation

Function

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion (Probable). {ECO:0000305}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:7588255}.

Disease Associations

Tissue Specificity

Expressed within glia and neurons in discrete regions of the brain. {ECO:0000269PubMed:12486153}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0017127	cholesterol transporter activity

Biological Process

GO:0006082	organic acid metabolic process
GO:0006699	bile acid biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0007420	brain development
GO:0007584	response to nutrient
GO:0007623	circadian rhythm
GO:0008203	cholesterol metabolic process
GO:0008211	glucocorticoid metabolic process
GO:0008584	male gonad development
GO:0009635	response to herbicide
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010212	response to ionizing radiation
GO:0010288	response to lead ion
GO:0010628	positive regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0016101	diterpenoid metabolic process
GO:0017085	response to insecticide
GO:0017143	insecticide metabolic process
GO:0018879	biphenyl metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0018958	phenol-containing compound metabolic process
GO:0018963	phthalate metabolic process
GO:0031667	response to nutrient levels
GO:0032367	intracellular cholesterol transport
GO:0032869	cellular response to insulin stimulus
GO:0034698	response to gonadotropin
GO:0035094	response to nicotine
GO:0035457	cellular response to interferon-alpha
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042747	circadian sleep/wake cycle, REM sleep
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0043627	response to estrogen
GO:0044255	cellular lipid metabolic process
GO:0044321	response to leptin
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045471	response to ethanol
GO:0046677	response to antibiotic
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048545	response to steroid hormone
GO:0050756	fractalkine metabolic process
GO:0050769	positive regulation of neurogenesis
GO:0050810	regulation of steroid biosynthetic process
GO:0051412	response to corticosterone
GO:0060992	response to fungicide
GO:0061370	testosterone biosynthetic process
GO:0071222	cellular response to lipopolysaccharide
GO:0071236	cellular response to antibiotic
GO:0071248	cellular response to metal ion
GO:0071276	cellular response to cadmium ion
GO:0071312	cellular response to alkaloid
GO:0071320	cellular response to cAMP
GO:0071333	cellular response to glucose stimulus
GO:0071346	cellular response to interferon-gamma
GO:0071371	cellular response to gonadotropin stimulus
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071373	cellular response to luteinizing hormone stimulus
GO:0071378	cellular response to growth hormone stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071549	cellular response to dexamethasone stimulus
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071872	cellular response to epinephrine stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0030061	mitochondrial crista
GO:0043005	neuron projection
GO:0043025	neuronal cell body