Version 5.4
Mus musculus Protein: Igsf1
Summary
InnateDB Protein IDBP-144493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igsf1
Protein Name immunoglobulin superfamily, member 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033442
InnateDB Gene IDBG-144491 (Igsf1)
Protein Structure
UniProt Annotation
Function Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin- stimulated transcription (By similarity). {ECO:0000250}.
Subcellular Localization Isoform 1: Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.Isoform 2: Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.Isoform 3: Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.Isoform 4: Secreted {ECO:0000305}.Isoform 5: Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0015026 coreceptor activity
GO:0034711 inhibin binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2147913
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TQA1
PhosphoSite PhosphoSite-Q7TQA1
TrEMBL
UniProt Splice Variant
Entrez Gene 209268
UniGene Mm.405513
RefSeq NP_808259
MGI ID
MGI Symbol Igsf1
OMIM
CCDS CCDS40964
HPRD
IMGT
EMBL AK030452 AK129126 AY227771 AY227772 AY227773 AY227774
GenPept AAP57079 AAP57080 AAP57081 AAP57082 BAC26969 BAC97936

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca