Version 5.4
Homo sapiens Protein: KRTAP26-1
Summary
InnateDB Protein IDBP-1446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRTAP26-1
Protein Name keratin associated protein 26-1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353742
InnateDB Gene IDBG-1444 (KRTAP26-1)
Protein Structure
UniProt Annotation
Function In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
Subcellular Localization
Disease Associations
Tissue Specificity Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla). {ECO:0000269PubMed:18647308}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005882 intermediate filament
Protein Structure and Domains
PDB ID
InterPro IPR007951 Keratin-associated protein, PMG type
PFAM PF05287
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PEX3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 388818
UniGene Hs.28704
RefSeq NP_981950
HUGO HGNC:33760
OMIM
CCDS CCDS13588
HPRD 14206
IMGT
EMBL AB096936 AM941740 BC057825
GenPept AAH57825 BAE46351 CAQ03502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca