InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sos2

Summary

InnateDB Protein

IDBP-144638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sos2

Protein Name

son of sevenless homolog 2 (Drosophila)

Synonyms

mSOS-2; SOS-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044866

InnateDB Gene

IDBG-144636 (Sos2)

Protein Structure

UniProt Annotation

Function

Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in most embryonic and adult tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

MGI:98355

InterPro

IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR007125 Histone core
IPR009072 Histone-fold
IPR023578 Ras guanine nucleotide exchange factor, domain

PFAM

PF00621
PF00618
PF00169
PF00617
PF00125

PRINTS

PIRSF

SMART

SM00325
SM00229
SM00233
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite