Version 5.4
Mus musculus Protein: Ube3c
Summary
InnateDB Protein IDBP-144653.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube3c
Protein Name ubiquitin protein ligase E3C
Synonyms AI853514; mKIAA0010;
Species Mus musculus
Ensembl Protein ENSMUSP00000045998
InnateDB Gene IDBG-144651 (Ube3c)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2140998
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000569 HECT
PFAM PF00612
PF00632
PRINTS
PIRSF
SMART SM00015
SM00119
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80U95
PhosphoSite PhosphoSite-Q80U95
TrEMBL
UniProt Splice Variant
Entrez Gene 100763
UniGene Mm.137746
RefSeq NP_598668
MGI ID
MGI Symbol Ube3c
OMIM
CCDS CCDS39042
HPRD
IMGT
EMBL AK029973 AK046056 AK049125 AK122187 BC021525 BC120731 BC137626
GenPept AAH21525 AAI20732 AAI37627 BAC26709 BAC32585 BAC33557 BAC65469

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca