InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xbp1

Summary

InnateDB Protein

IDBP-144747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xbp1

Protein Name

X-box binding protein 1

Synonyms

D11Ertd39e; TREB-5; TREB5; XBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054852

InnateDB Gene

IDBG-144745 (Xbp1)

Protein Structure

UniProt Annotation

Function

Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE) (By similarity). Isoform 2 is involved in controlling the production of interleukin-6. {ECO:0000250, ECO:0000269PubMed:12612580, ECO:0000269PubMed:14559994}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002070	epithelial cell maturation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031017	exocrine pancreas development
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051602	response to electrical stimulus
GO:0060096	serotonin secretion, neurotransmission
GO:0060691	epithelial cell maturation involved in salivary gland development
GO:0071236	cellular response to antibiotic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
GO:1901800	positive regulation of proteasomal protein catabolic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:98970

InterPro

IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

PFAM

PF00170
PF07716

PRINTS

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35426

PhosphoSite

PhosphoSite-O35426

TrEMBL

UniProt Splice Variant

Entrez Gene

22433

UniGene

RefSeq

NP_038870

MGI ID

MGI Symbol

Xbp1

OMIM

CCDS

CCDS24400

HPRD

IMGT

EMBL

AB036745 AF027963 AF443192 AL662876 BC008153 BC029197

GenPept

AAB81862 AAH08153 AAH29197 AAL60202 BAB13793 CAI24935