Mus musculus Protein: Lrrc26
Summary
InnateDB Protein IDBP-144876.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrc26
Protein Name leucine rich repeat containing 26
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000028337
InnateDB Gene IDBG-144874 (Lrrc26)
Protein Structure
UniProt Annotation
Function Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006811 ion transport
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0008076 voltage-gated potassium channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2385129
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91W20
PhosphoSite PhosphoSite-Q91W20
TrEMBL
UniProt Splice Variant
Entrez Gene 227618
UniGene Mm.275228
RefSeq NP_666229
MGI ID
MGI Symbol Lrrc26
OMIM
CCDS CCDS15763
HPRD
IMGT
EMBL AK137758 AK142669 AL732309 BC004853 BC024531 BC024539
GenPept AAH04853 AAH24531 AAH24539 BAE23492 BAE25154 CAM14683