Mus musculus Protein: Kcnn2 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Protein | IDBP-144909.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Kcnn2 | ||||||||||||||
Protein Name | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000067884 | ||||||||||||||
InnateDB Gene | IDBG-144907 (Kcnn2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. {ECO:0000269PubMed:11557517, ECO:0000269PubMed:13679367, ECO:0000269PubMed:14657188}. | ||||||||||||||
Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Expressed in atrial and ventricular myocytes with higher levels in atrial myocytes (at protein level). Highly expressed in brain, liver and colon with low levels in kidney and testis. In colon, detected in smooth muscle cells. {ECO:0000269PubMed:11557517, ECO:0000269PubMed:13679367, ECO:0000269PubMed:16055520}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:2153182 | ||||||||||||||
InterPro |
IPR004178
Calmodulin-binding domain IPR013099 Two pore domain potassium channel domain IPR015449 Potassium channel, calcium-activated, SK |
||||||||||||||
PFAM |
PF02888
PF07885 PF03530 |
||||||||||||||
PRINTS |
PR01451
|
||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM01053
|
||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | P58390 | ||||||||||||||
PhosphoSite | PhosphoSite-Q3UF29 | ||||||||||||||
TrEMBL | Q8C7F3 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 140492 | ||||||||||||||
UniGene | Mm.458654 | ||||||||||||||
RefSeq | |||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Kcnn2 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AC099590 AC101593 AC121957 AC122852 AF357240 AF533008 AK033158 AK050390 AK149082 AY123778 BC125475 BC137656 CH466528 | ||||||||||||||
GenPept | AAI25476 AAI37657 AAK48901 AAM88568 AAQ10283 BAC28176 BAC34231 BAE28732 EDL09992 | ||||||||||||||