InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 4930444A02Rik

Summary

InnateDB Protein

IDBP-144915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

4930444A02Rik

Protein Name

RIKEN cDNA 4930444A02 gene

Synonyms

4930444A02Rik; Sgk196;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053802

InnateDB Gene

IDBG-144913 (4930444A02Rik)

Protein Structure

UniProt Annotation

Function

Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N- acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019200	carbohydrate kinase activity

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0006493	protein O-linked glycosylation
GO:0007420	brain development
GO:0007611	learning or memory
GO:0019233	sensory perception of pain
GO:0046835	carbohydrate phosphorylation
GO:0050905	neuromuscular process