InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fars2

Summary

InnateDB Protein

IDBP-144940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fars2

Protein Name

phenylalanine-tRNA synthetase 2 (mitochondrial)

Synonyms

Fars1; pheRS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021857

InnateDB Gene

IDBG-144938 (Fars2)

Protein Structure

UniProt Annotation

Function

Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004826	phenylalanine-tRNA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006432	phenylalanyl-tRNA aminoacylation
GO:0008033	tRNA processing
GO:0043039	tRNA aminoacylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1917205

InterPro

IPR002319 Phenylalanyl-tRNA synthetase
IPR004530 Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding
IPR006195 Aminoacyl-tRNA synthetase, class II

PFAM

PF01409
PF03147

PRINTS

PIRSF

SMART

SM00896

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99M01