Version 5.4
Mus musculus Protein: Rnf170
Summary
InnateDB Protein IDBP-145212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf170
Protein Name ring finger protein 170
Synonyms 6720407G21Rik; AI481227;
Species Mus musculus
Ensembl Protein ENSMUSP00000014022
InnateDB Gene IDBG-145210 (Rnf170)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. {ECO:0000269PubMed:21610068}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:21610068}; Multi-pass membrane protein {ECO:0000269PubMed:21610068}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1924983
InterPro IPR001841 Zinc finger, RING-type
IPR010652 Protein of unknown function DUF1232
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF06803
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CBG9
PhosphoSite PhosphoSite-
TrEMBL D3Z0A0
UniProt Splice Variant
Entrez Gene 77733
UniGene Mm.468544
RefSeq NP_084241
MGI ID
MGI Symbol Rnf170
OMIM
CCDS CCDS22207
HPRD
IMGT
EMBL AC093366 AK036051 AK042063 AK044579 AK080591 AK152760 BC031383 BC114210 BC138930 BC145718 CH466580
GenPept AAH31383 AAI14211 AAI38931 AAI45719 BAC29287 BAC31147 BAC31988 BAC37951 BAE31474 EDL32805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca