InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polm

Summary

InnateDB Protein

IDBP-145250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polm

Protein Name

polymerase (DNA directed), mu

Synonyms

AI462166; B230309I03Rik; Tdt-N;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020767

InnateDB Gene

IDBG-145248 (Polm)

Protein Structure

UniProt Annotation

Function

Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. {ECO:0000269PubMed:16860755, ECO:0000269PubMed:17483519}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0030183	B cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1860191

InterPro

IPR001357 BRCT domain
IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
IPR002008 DNA polymerase, family X, beta-like
IPR002054 DNA-directed DNA polymerase X
IPR010996 DNA polymerase beta-like, N-terminal domain
IPR018944 DNA polymerase lambda, fingers domain
IPR022312 DNA polymerase family X

PFAM

PF00533
PF12738
PF10391

PRINTS

PR00871
PR00870
PR00869

PIRSF

PIRSF000817

SMART

SM00292
SM00483

TIGRFAMs

Post-translational Modifications

Modification

Cross-References