InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdpk1

Summary

InnateDB Protein

IDBP-145255.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Pdpk1

Protein Name

3-phosphoinositide dependent protein kinase 1

Synonyms

Pdk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061942

InnateDB Gene

IDBG-145251 (Pdpk1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004676	3-phosphoinositide-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005158	insulin receptor binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0006972	hyperosmotic response
GO:0007165	signal transduction
GO:0018107	peptidyl-threonine phosphorylation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032148	activation of protein kinase B activity
GO:0032869	cellular response to insulin stimulus
GO:0035556	intracellular signal transduction
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048041	focal adhesion assembly
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

MGI:1338068

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt