InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Anp32b

Summary

InnateDB Protein

IDBP-145258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anp32b

Protein Name

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

Synonyms

2410015B15Rik; PAL31; PHAPI2a; Ssp29;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099990

InnateDB Gene

IDBG-145256 (Anp32b)

Protein Structure

UniProt Annotation

Function

Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Note=Accumulates in the nuclei at the S phase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042393	histone binding
GO:0070063	RNA polymerase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001944	vasculature development
GO:0006334	nucleosome assembly
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0021591	ventricular system development
GO:0045596	negative regulation of cell differentiation
GO:0046827	positive regulation of protein export from nucleus
GO:0048839	inner ear development
GO:0060021	palate development