InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amdhd2

Summary

InnateDB Protein

IDBP-145284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amdhd2

Protein Name

amidohydrolase domain containing 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036141

InnateDB Gene

IDBG-145282 (Amdhd2)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the N-glycolyl group from N- glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0019262	N-acetylneuraminate catabolic process

Cellular Component

Protein Structure and Domains

PDB ID

MGI:2443978

InterPro

IPR003764 N-acetylglucosamine-6-phosphate deacetylase
IPR006680 Amidohydrolase 1
IPR011059 Metal-dependent hydrolase, composite domain
IPR013108 Amidohydrolase 3

PFAM

PF01979
PF07969

PRINTS

PIRSF

PIRSF038994

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8JZV7