InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amd1

Summary

InnateDB Protein

IDBP-145378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amd1

Protein Name

S-adenosylmethionine decarboxylase 1

Synonyms

1; AdoMetDC; adoMetDC1; Amd-1; SAMDC; SAMDC 1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097528

InnateDB Gene

IDBG-145376 (Amd1)

Protein Structure

UniProt Annotation

Function

Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000269PubMed:22391449}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in embryonic stem cells; subsequently down-regulated in differentiating neural precursor cells. {ECO:0000269PubMed:22391449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004014	adenosylmethionine decarboxylase activity
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006557	S-adenosylmethioninamine biosynthetic process
GO:0006597	spermine biosynthetic process
GO:0008295	spermidine biosynthetic process