Mus musculus Protein: Trim14
Summary
InnateDB Protein IDBP-145381.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim14
Protein Name tripartite motif-containing 14
Synonyms 5830400N10Rik; pub;
Species Mus musculus
Ensembl Protein ENSMUSP00000038719
InnateDB Gene IDBG-145379 (Trim14)
Protein Structure
UniProt Annotation
Function Inhibits the transcriptional activity of SPI1 in a dose- dependent manner. {ECO:0000269PubMed:14592421}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed with high level in spleen, thymus, liver and testis. Expressed with low level in the brain, kidney, and skeletal muscle. Expressed in various differentiation stages of B-lymphocytes. {ECO:0000269PubMed:14592421}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0032897 negative regulation of viral transcription
GO:0045087 innate immune response
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1921985
InterPro IPR000315 Zinc finger, B-box
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
PFAM PF00643
PF00622
PF13765
PRINTS PR01407
PIRSF
SMART SM00336
SM00449
SM00589
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BVW3
PhosphoSite PhosphoSite-Q8BVW3
TrEMBL Q3TA17
UniProt Splice Variant
Entrez Gene 74735
UniGene Mm.240252
RefSeq NP_083353
MGI ID
MGI Symbol Trim14
OMIM
CCDS CCDS18153
HPRD
IMGT
EMBL AB117644 AK017887 AK076277 AK172159 AK172895 AL683884 BC116738 BC119130
GenPept AAI16739 AAI19131 BAB30988 BAC36286 BAD02394 BAD32173 BAE42853 CAM13793