InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hprt

Summary

InnateDB Protein

IDBP-145411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hprt

Protein Name

hypoxanthine guanine phosphoribosyl transferase

Synonyms

C81579; HPGRT; Hprt1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026723

InnateDB Gene

IDBG-145409 (Hprt)

Protein Structure

UniProt Annotation

Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004422	hypoxanthine phosphoribosyltransferase activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0052657	guanine phosphoribosyltransferase activity

Biological Process

GO:0001975	response to amphetamine
GO:0006164	purine nucleotide biosynthetic process
GO:0006166	purine ribonucleoside salvage
GO:0006168	adenine salvage
GO:0006178	guanine salvage
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0009116	nucleoside metabolic process
GO:0019835	cytolysis
GO:0021756	striatum development
GO:0021895	cerebral cortex neuron differentiation
GO:0021954	central nervous system neuron development
GO:0032263	GMP salvage
GO:0032264	IMP salvage
GO:0042417	dopamine metabolic process
GO:0043103	hypoxanthine salvage
GO:0045964	positive regulation of dopamine metabolic process
GO:0046038	GMP catabolic process
GO:0046040	IMP metabolic process
GO:0046083	adenine metabolic process
GO:0046100	hypoxanthine metabolic process
GO:0046651	lymphocyte proliferation
GO:0048813	dendrite morphogenesis
GO:0051289	protein homotetramerization