InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dclk1

Summary

InnateDB Protein

IDBP-145414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dclk1

Protein Name

doublecortin-like kinase 1

Synonyms

1700113D08Rik; 2810480F11Rik; AI836758; Click-I; Cpg16; Dcamkl1; Dcl; Dclk; mKIAA0369;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050034

InnateDB Gene

IDBG-145412 (Dclk1)

Protein Structure

UniProt Annotation

Function

Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0009615	response to virus
GO:0021952	central nervous system projection neuron axonogenesis
GO:0030900	forebrain development
GO:0035556	intracellular signal transduction
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1330861

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003533 Doublecortin domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF03607

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00537
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt