InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ntn3

Summary

InnateDB Protein

IDBP-145431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ntn3

Protein Name

netrin 3

Synonyms

Ntn2l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024931

InnateDB Gene

IDBG-249738 (Ntn3)

Protein Structure

UniProt Annotation

Function

Netrins control guidance of CNS commissural axons and peripheral motor axons. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:11231084}.

Disease Associations

Tissue Specificity

Very low levels at E10.5 to E12.5 in dorsal root ganglia. High levels in motor neurons at E13.5, E14.5 and E15.5. At E11.5 also expressed in the developing limb buds. {ECO:0000269PubMed:10381568, ECO:0000269PubMed:11231084}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007409	axonogenesis
GO:0007520	myoblast fusion

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

MGI:1341188

InterPro

IPR001134 Netrin domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type

PFAM

PF00053
PF00055
PF01759

PRINTS

PIRSF

SMART

SM00180
SM00136
SM00643

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R1A3