Version 5.4
Mus musculus Protein: Thyn1
Summary
InnateDB Protein IDBP-145547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thyn1
Protein Name thymocyte nuclear protein 1
Synonyms D730042P09Rik; HSPC144; MDS012; MY105; Thy28;
Species Mus musculus
Ensembl Protein ENSMUSP00000037614
InnateDB Gene IDBG-145545 (Thyn1)
Protein Structure
UniProt Annotation
Function Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269PubMed:23434322}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14580360, ECO:0000269PubMed:14601557}.
Disease Associations
Tissue Specificity Expressed in the medulla containing mature thymocytes, but not the cortex having immature thymocytes (at protein level). Abundant expression seen in testis, liver, brain and kidney with lower levels of the expression in thymus, spleen, heart and stomach. {ECO:0000269PubMed:12384300, ECO:0000269PubMed:14580360, ECO:0000269PubMed:14601557}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1925112
InterPro IPR002740 EVE domain
IPR015947 PUA-like domain
PFAM PF01878
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YJ3
PhosphoSite PhosphoSite-Q91YJ3
TrEMBL
UniProt Splice Variant
Entrez Gene 77862
UniGene
RefSeq NP_653126
MGI ID
MGI Symbol Thyn1
OMIM
CCDS CCDS22937
HPRD
IMGT
EMBL AB080370 BC016594
GenPept AAH16594 BAC21100

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca