InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psmd2

Summary

InnateDB Protein

IDBP-145584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psmd2

Protein Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

Synonyms

9430095H01Rik; AA407121; TEG-190; Tex190;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007212

InnateDB Gene

IDBG-145582 (Psmd2)

Protein Structure

UniProt Annotation

Function

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 119 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	119 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0042176	regulation of protein catabolic process
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0000502	proteasome complex
GO:0005838	proteasome regulatory particle
GO:0022624	proteasome accessory complex

Protein Structure and Domains

PDB ID

MGI:1096584

InterPro

IPR002015 Proteasome/cyclosome repeat
IPR016024 Armadillo-type fold
IPR016643 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit

PFAM

PF01851

PRINTS

PIRSF

PIRSF015965

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VDM4

PhosphoSite

PhosphoSite-Q8VDM4

TrEMBL

Q9CRK7

UniProt Splice Variant

Entrez Gene

21762

UniGene

Mm.488817

RefSeq

NP_598862

MGI ID

MGI Symbol

Psmd2

OMIM

CCDS

CCDS28053

HPRD

IMGT

EMBL

AK020524 AK159756 AK166816 AK167326 BC005592 BC021508 BC023049 BC024830 BC027388 BC027767 BC027822 BC028851 BC031128 CH466521

GenPept

AAH05592 AAH21508 AAH23049 AAH24830 AAH27388 AAH27767 AAH27822 AAH28851 AAH31128 BAB32124 BAE35347 BAE39042 BAE39428 EDK97585