Version 5.4
| Mus musculus Protein: Tbc1d2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-145613.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tbc1d2 | ||||||||
| Protein Name | TBC1 domain family, member 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000081670 | ||||||||
| InnateDB Gene | IDBG-145611 (Tbc1d2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2652885 | ||||||||
| InterPro |
IPR000195
Rab-GTPase-TBC domain IPR001849 Pleckstrin homology domain |
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| PFAM |
PF00566
PF00169 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00164
SM00233 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | B1AVH7 | ||||||||
| PhosphoSite | PhosphoSite-NP_941066 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 381605 | ||||||||
| UniGene | Mm.331595 | ||||||||
| RefSeq | NP_941066 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tbc1d2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18155 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK041359 AK148254 AL683884 BX571848 BX682536 | ||||||||
| GenPept | BAC30918 BAE28440 CAM13787 CAM17021 CAM17022 CAM27677 CAM27678 | ||||||||