Version 5.4
Mus musculus Protein: Gimap1
Summary
InnateDB Protein IDBP-145621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gimap1
Protein Name GTPase, IMAP family member 1
Synonyms IAP38; imap; Imap38;
Species Mus musculus
Ensembl Protein ENSMUSP00000062108
InnateDB Gene IDBG-487221 (Gimap1)
Protein Structure
UniProt Annotation
Function May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells. {ECO:0000269PubMed:20194894}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane.
Disease Associations
Tissue Specificity Detected in mature B-cells and thymocytes (at protein level). Detected in lymph nodes and thymocytes. {ECO:0000269PubMed:20194894}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:109368
InterPro IPR006703 AIG1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04548
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70224
PhosphoSite PhosphoSite-P70224
TrEMBL Q3TFI6
UniProt Splice Variant
Entrez Gene 16205
UniGene
RefSeq NP_787056
MGI ID
MGI Symbol Gimap1
OMIM
CCDS CCDS20113
HPRD
IMGT
EMBL AC153894 AJ133125 AK156732 AK169133 BC132601 BC132603 Y08026
GenPept AAI32602 AAI32604 BAE33826 BAE40912 CAA69283 CAB53101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca