InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nbea

Summary

InnateDB Protein

IDBP-145655.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nbea

Protein Name

neurobeachin

Synonyms

Lyst2; mKIAA1544;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029374

InnateDB Gene

IDBG-145653 (Nbea)

Protein Structure

UniProt Annotation

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking. {ECO:0000269PubMed:11102458, ECO:0000303PubMed:11102458}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11102458}; Peripheral membrane protein {ECO:0000269PubMed:11102458}. Endomembrane system {ECO:0000269PubMed:11102458}; Peripheral membrane protein {ECO:0000269PubMed:11102458}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269PubMed:11102458}; Peripheral membrane protein {ECO:0000269PubMed:11102458}. Note=Associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell bodies and cell processes. Concentrated at the postsynaptic plasma membrane of a subpopulation of synapses.

Disease Associations

Tissue Specificity

Forebrain, brainstem and cerebellum. {ECO:0000269PubMed:11102458}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006605	protein targeting
GO:0006892	post-Golgi vesicle-mediated transport
GO:0008104	protein localization

Cellular Component

GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1347075

InterPro

IPR000409 BEACH domain
IPR001680 WD40 repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR010508 Domain of unknown function DUF1088
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain

PFAM

PF02138
PF00400
PF06469

PRINTS

PIRSF

SMART

SM01026
SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EPN1