Version 5.4
Mus musculus Protein: Oc90
Summary
InnateDB Protein IDBP-145717.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oc90
Protein Name otoconin 90
Synonyms oc95; Ocn-95; PLA2L; Pla2ll;
Species Mus musculus
Ensembl Protein ENSMUSP00000062865
InnateDB Gene IDBG-145713 (Oc90)
Protein Structure
UniProt Annotation
Function Major protein of the utricular and saccular otoconia. It is unlikely that this protein has phospholipase A2 activity.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity In the embryo, highly expressed in the developing otocyst with weak expression in the brain. Also expressed in nonsensory epithelia of both the vestibular and cochlear portions of the developing inner ear. Not expressed in adult or embryonic macular sensory epithelia.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005578 proteinaceous extracellular matrix
Protein Structure and Domains
PDB ID MGI:1313269
InterPro IPR001211 Phospholipase A2
IPR016090 Phospholipase A2 domain
PFAM PF05826
PF00068
PRINTS PR00389
PIRSF
SMART SM00085
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0L3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 18256
UniGene Mm.41776
RefSeq NP_035083
MGI ID
MGI Symbol Oc90
OMIM
CCDS CCDS27508
HPRD
IMGT
EMBL AF091846 AF091847 AF093591 AK012981
GenPept AAC99455 AAC99456 AAD08924 BAB28578

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca