Version 5.4
Mus musculus Protein: Inpp4a
Summary
InnateDB Protein IDBP-145744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Inpp4a
Protein Name inositol polyphosphate-4-phosphatase, type I
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000057233
InnateDB Gene IDBG-145740 (Inpp4a)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. Involved in the regulation of megakaryocyte and fibroblast proliferation. Regulates cell growth downstream of transcription factor GATA-1. {ECO:0000269PubMed:11087841}.
Subcellular Localization
Disease Associations
Tissue Specificity Spleen, skeletal muscle, lung and uterus. {ECO:0000269PubMed:11485317}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
Biological Process
GO:0006798 polyphosphate catabolic process
GO:0016311 dephosphorylation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
Cellular Component
Protein Structure and Domains
PDB ID MGI:1931123
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EPW0
PhosphoSite PhosphoSite-Q9EPW0
TrEMBL
UniProt Splice Variant
Entrez Gene 269180
UniGene Mm.5294
RefSeq NP_001277728
MGI ID
MGI Symbol Inpp4a
OMIM
CCDS
HPRD
IMGT
EMBL AF317838 AK035867
GenPept AAG40778 BAC29220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca