Version 5.4
| Mus musculus Protein: Galnt12 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-145854.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Galnt12 | ||||||||
| Protein Name | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000045721 | ||||||||
| InnateDB Gene | IDBG-145852 (Galnt12) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc- Muc5AC glycopeptide, but no detectable activity to mono-GalNAc- glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2444664 | ||||||||
| InterPro |
IPR000772
Ricin B lectin domain IPR001173 Glycosyltransferase 2-like IPR029044 Nucleotide-diphospho-sugar transferases |
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| PFAM |
PF00652
PF14200 PF00535 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00458
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8BGT9 | ||||||||
| PhosphoSite | PhosphoSite-Q8BGT9 | ||||||||
| TrEMBL | Q60GT3 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 230145 | ||||||||
| UniGene | Mm.132246 | ||||||||
| RefSeq | NP_766281 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Galnt12 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18158 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB175680 AK033638 AK042133 AK156751 AL831741 BC056425 | ||||||||
| GenPept | AAH56425 BAC28401 BAC31179 BAD52068 BAE33836 | ||||||||