InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnk3

Summary

InnateDB Protein

IDBP-145862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnk3

Protein Name

potassium channel, subfamily K, member 3

Synonyms

cTBAK-1; TASK; Task-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098987

InnateDB Gene

IDBG-145858 (Kcnk3)

Protein Structure

UniProt Annotation

Function

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Very strong expression in heart, also detected in kidney, brain, skin, testis, lung, skeletal muscle, small intestine and stomach. Not detected in liver, thymus or spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005252	open rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0022841	potassium ion leak channel activity
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007420	brain development
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0042493	response to drug
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0071294	cellular response to zinc ion
GO:0071456	cellular response to hypoxia
GO:0071805	potassium ion transmembrane transport
GO:0090102	cochlea development

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1100509

InterPro

IPR003092 Two pore domain potassium channel, TASK family
IPR003280 Two pore domain potassium channel
IPR005406 Potassium channel subfamily K member 3
IPR013099 Two pore domain potassium channel domain

PFAM

PF07885

PRINTS

PR01095
PR01333
PR01584

PIRSF

PIRSF038061

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt