InnateDB Protein
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IDBP-14589.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RMI2
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Protein Name
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RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310356
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InnateDB Gene
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IDBG-14585 (RMI2)
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Protein Structure
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Function |
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress- induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269PubMed:18923082, ECO:0000269PubMed:18923083}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18923082}. Note=Colocalizes with BLM at nuclear DNA repair foci.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96E14
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PhosphoSite |
PhosphoSite-Q96E14
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
116028
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UniGene |
Hs.733558
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RefSeq |
NP_689521
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HUGO |
HGNC:28349
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OMIM |
612426
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CCDS |
CCDS10548
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HPRD |
14497
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IMGT |
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EMBL |
AC009121
AK123764
BC013040
BC022427
BC031016
BC039361
CH471112
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GenPept |
AAH13040
AAH22427
AAH31016
AAH39361
BAG53958
EAW85155
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