InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnq3

Summary

InnateDB Protein

IDBP-145921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnq3

Protein Name

potassium voltage-gated channel, subfamily Q, member 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063380

InnateDB Gene

IDBG-145919 (Kcnq3)

Protein Structure

UniProt Annotation

Function

Probably important in the regulation of neuronal excitability. Associates with KCNQ2 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005267	potassium channel activity

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0033268	node of Ranvier
GO:0043194	axon initial segment

Protein Structure and Domains

PDB ID

MGI:1336181

InterPro

IPR003091 Potassium channel
IPR003937 Potassium channel, voltage dependent, KCNQ
IPR003948 Potassium channel, voltage dependent, KCNQ3
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
IPR020969 Ankyrin-G binding site

PFAM

PF00520
PF07885
PF03520
PF11956

PRINTS

PR00169
PR01459
PR01462

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K3F6