InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Col15a1

Summary

InnateDB Protein

IDBP-145939.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Col15a1

Protein Name

collagen, type XV, alpha 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099981

InnateDB Gene

IDBG-145937 (Col15a1)

Protein Structure

UniProt Annotation

Function

Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.Restin potently inhibits angiogenesis.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in testis, brain, heart, kidney, skeletal muscle and skin (at protein level). Detected in heart and skeletal muscle. {ECO:0000269PubMed:9339358}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0005581	collagen trimer
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88449

InterPro

IPR001791 Laminin G domain
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR010515 Collagenase NC10/endostatin
IPR016187 C-type lectin fold

PFAM

PF00054
PF02210
PF01391
PF06482

PRINTS

PIRSF

SMART

SM00210
SM00282

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35206