Version 5.4
Mus musculus Protein: Txndc5
Summary
InnateDB Protein IDBP-145982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txndc5
Protein Name thioredoxin domain containing 5
Synonyms AL022641; ERp46; PC-TRP;
Species Mus musculus
Ensembl Protein ENSMUSP00000041839
InnateDB Gene IDBG-145980 (Txndc5)
Protein Structure
UniProt Annotation
Function Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. {ECO:0000269PubMed:12930873, ECO:0000269PubMed:14971039}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:12930873}.
Disease Associations
Tissue Specificity Expressed at high levels in plasma cells and at very low levels in all other cells and tissues examined (at protein level). {ECO:0000269PubMed:14971039}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0016853 isomerase activity
Biological Process
GO:0006457 protein folding
GO:0034976 response to endoplasmic reticulum stress
GO:0043277 apoptotic cell clearance
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID MGI:2145316
InterPro IPR005788 Disulphide isomerase
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91W90
PhosphoSite PhosphoSite-Q91W90
TrEMBL Q3UWX1
UniProt Splice Variant
Entrez Gene 105245
UniGene Mm.28622
RefSeq NP_663342
MGI ID
MGI Symbol Txndc5
OMIM
CCDS CCDS26463
HPRD
IMGT
EMBL AK136046 AK142049 AK169680 AY243534 AY548112 BC016252 BC024505 BC046789
GenPept AAH16252 AAH24505 AAH46789 AAP68841 AAS55652 BAE22793 BAE24925 BAE41300

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca