InnateDB Protein
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IDBP-146015.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wwtr1
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Protein Name
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WW domain containing transcription regulator 1
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Synonyms
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2310058J06Rik; 2610021I22Rik; C78399; Taz;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029380
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InnateDB Gene
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IDBG-146013 (Wwtr1)
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Protein Structure
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Function |
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11118213}. Cytoplasm {ECO:0000269PubMed:11118213}. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in kidney, heart, placenta and lung. {ECO:0000269PubMed:11118213}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
57
[view]
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Protein-Protein |
57
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001649
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osteoblast differentiation
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006469
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negative regulation of protein kinase activity
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GO:0008284
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positive regulation of cell proliferation
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GO:0010718
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positive regulation of epithelial to mesenchymal transition
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GO:0017145
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stem cell division
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GO:0032835
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glomerulus development
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GO:0035329
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hippo signaling
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GO:0035414
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negative regulation of catenin import into nucleus
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GO:0045599
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negative regulation of fat cell differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0060271
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cilium morphogenesis
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GO:0060390
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regulation of SMAD protein import into nucleus
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GO:0060828
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regulation of canonical Wnt signaling pathway
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GO:0072307
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regulation of metanephric nephron tubule epithelial cell differentiation
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GO:0090090
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negative regulation of canonical Wnt signaling pathway
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Cellular Component |
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PDB ID |
MGI:1917649
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InterPro |
IPR001202
WW domain
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PFAM |
PF00397
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PRINTS |
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PIRSF |
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SMART |
SM00456
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EPK5
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PhosphoSite |
PhosphoSite-Q9EPK5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
97064
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UniGene |
Mm.405324
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RefSeq |
NP_598545
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MGI ID |
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MGI Symbol |
Wwtr1
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OMIM |
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CCDS |
CCDS38434
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HPRD |
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IMGT |
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EMBL |
AJ299430
AK142299
AK142720
BC004640
BC014727
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GenPept |
AAH04640
AAH14727
BAE25019
BAE25174
CAC17733
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