Homo sapiens Protein: ZFR
Summary
InnateDB Protein IDBP-14602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFR
Protein Name zinc finger RNA binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265069
InnateDB Gene IDBG-14600 (ZFR)
Protein Structure
UniProt Annotation
Function Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney. {ECO:0000269PubMed:11574164}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003604 Zinc finger, U1-type
IPR006561 DZF domain
IPR015880 Zinc finger, C2H2-like
IPR022755 Zinc finger, double-stranded RNA binding
PFAM PF07528
PF12171
PRINTS
PIRSF
SMART SM00451
SM00572
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96KR1
PhosphoSite PhosphoSite-Q96KR1
TrEMBL B3KP82
UniProt Splice Variant
Entrez Gene 51663
UniGene Hs.435231
RefSeq NP_057191
HUGO HGNC:17277
OMIM 615635
CCDS CCDS34139
HPRD 15730
IMGT
EMBL AC008949 AF100742 AJ314790 AK025481 AK055938 AK295297 AL137258 BC030540 BC051893 BC062986 BC107417 BC137084
GenPept AAD40385 AAH30540 AAH51893 AAH62986 AAI07418 AAI37085 BAB15147 BAG51594 BAG58279 CAB70659 CAC40818