InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrc6

Summary

InnateDB Protein

IDBP-146032.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrc6

Protein Name

leucine rich repeat containing 6 (testis)

Synonyms

LRTP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023006

InnateDB Gene

IDBG-146030 (Lrrc6)

Protein Structure

UniProt Annotation

Function

May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10775177}. Cell projection, cilium {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis-specific (at protein level). Expressed in testis. Abundant expression in late prophase of meiosis I with a dramatic decrease after the first meiotic division. {ECO:0000269PubMed:10775177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0003341	cilium movement
GO:0008584	male gonad development
GO:0030317	sperm motility
GO:0036158	outer dynein arm assembly
GO:0036159	inner dynein arm assembly
GO:0044458	motile cilium assembly
GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry
GO:0061458	reproductive system development