InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf13

Summary

InnateDB Protein

IDBP-146123.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf13

Protein Name

ring finger protein 13

Synonyms

2010001H16Rik; Rzf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049331

InnateDB Gene

IDBG-146121 (Rnf13)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. {ECO:0000269PubMed:19292867}.

Subcellular Localization

Late endosome membrane; Single-pass membrane protein. Lysosome membrane. Cytoplasm, cytosol. Nucleus inner membrane. Note=The mature protein is subjected to extensive proteolysis that leads to the shedding of the ectodomain into the lumen of vesicles and the release of the C-terminal fragment into the cytosol. Not detected in early endosomes. Treatment of the cells with either PMA or ionomycin stabilizes the full-length protein which relocalizes to recycling endosomes and to the inner nuclear membrane.

Disease Associations

Tissue Specificity

Expressed in the brain, heart, kidney, liver and spleen. Higher expression in adult tissues compared to the embryonic counterparts. {ECO:0000269PubMed:19292867}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding