InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxw5

Summary

InnateDB Protein

IDBP-146181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxw5

Protein Name

F-box and WD-40 domain protein 5

Synonyms

AI159739; Fbw5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015239

InnateDB Gene

IDBG-146179 (Fbxw5)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. {ECO:0000250, ECO:0000269PubMed:23314863}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in adult and embryonal tissues. {ECO:0000269PubMed:10531037}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051298	centrosome duplication