InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr4a3

Summary

InnateDB Protein

IDBP-146209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr4a3

Protein Name

nuclear receptor subfamily 4, group A, member 3

Synonyms

AI573420; CHN; CSMF; MINOR; NOR-1; Nor1; TEC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030025

InnateDB Gene

IDBG-146207 (Nr4a3)

Protein Structure

UniProt Annotation

Function

Binds to the B1A response-element. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest levels of expression in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001707	mesoderm formation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007411	axon guidance
GO:0021766	hippocampus development
GO:0030522	intracellular receptor signaling pathway
GO:0030534	adult behavior
GO:0031100	organ regeneration
GO:0042472	inner ear morphogenesis
GO:0042542	response to hydrogen peroxide
GO:0043066	negative regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045787	positive regulation of cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048752	semicircular canal morphogenesis
GO:0050885	neuromuscular process controlling balance
GO:0060005	vestibular reflex
GO:2000108	positive regulation of leukocyte apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:1352457

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003072 Orphan nuclear receptor, NOR1 type
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01284
PR01286

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt