InnateDB Protein
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IDBP-146244.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Stx17
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Protein Name
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syntaxin 17
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Synonyms
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4833418L03Rik; 6330411F21Rik; 9030425C21Rik; AW048351;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068087
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InnateDB Gene
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IDBG-146240 (Stx17)
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Protein Structure
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Function |
SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Smooth endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria. A significant amount is also present in the cytosol (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1914977
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InterPro |
IPR000727
Target SNARE coiled-coil domain
IPR010989
t-SNARE
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PFAM |
PF05739
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PRINTS |
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PIRSF |
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SMART |
SM00397
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D0I4
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PhosphoSite |
PhosphoSite-Q9D0I4
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TrEMBL |
B1AVI2
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UniProt Splice Variant |
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Entrez Gene |
67727
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UniGene |
Mm.171334
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RefSeq |
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MGI ID |
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MGI Symbol |
Stx17
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OMIM |
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CCDS |
CCDS18164
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HPRD |
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IMGT |
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EMBL |
AK011400
AK018526
AK034718
AK154503
AL683893
BC028639
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GenPept |
AAH28639
BAB27592
BAB31255
BAC28806
BAE32634
CAM14010
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