Version 5.4
Mus musculus Protein: Polr2h
Summary
InnateDB Protein IDBP-146291.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr2h
Protein Name polymerase (RNA) II (DNA directed) polypeptide H
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021405
InnateDB Gene IDBG-146289 (Polr2h)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0001055 RNA polymerase II activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006383 transcription from RNA polymerase III promoter
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2384309
InterPro IPR005570 RNA polymerase, Rpb8
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF03870
PRINTS
PIRSF PIRSF000779
SMART SM00658
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q923G2
PhosphoSite PhosphoSite-Q923G2
TrEMBL
UniProt Splice Variant
Entrez Gene 245841
UniGene
RefSeq NP_663607
MGI ID
MGI Symbol Polr2h
OMIM
CCDS CCDS28058
HPRD
IMGT
EMBL AK146429 AK161617 BC002306 BC092087 BC125612 BC125638
GenPept AAH02306 AAH92087 AAI25613 AAI25639 BAE27163 BAE36495

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca